Heterobenzylic C(sp³)─H Acylation of Isoindolinones via Photoinduced Intermolecular Hydrogen Atom Transfer Strategy

Karthick Muthuvel; Chandrasekaran Sivaraj; Thirumanavelan Gandhi

doi:10.1055/a-2705-8764

Synlett, Table of Contents

Synlett
DOI: 10.1055/a-2705-8764

Letter

Heterobenzylic C(sp³)─H Acylation of Isoindolinones via Photoinduced Intermolecular Hydrogen Atom Transfer Strategy

Authors

Karthick Muthuvel

¹Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, India (Ringgold ID: RIN30026)
Chandrasekaran Sivaraj

¹Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, India (Ringgold ID: RIN30026)
Thirumanavelan Gandhi

¹Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, India (Ringgold ID: RIN30026)

Abstract

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Heterobenzylic C(sp³)−H functionalization of isoindolinones remains challenging yet highly desirable. Herein, we present a photo-induced hydrogen atom transfer (HAT) strategy for heterobenzylic C(sp³)−H acylation of isoindolinones using acyl azolium salts under mild reaction conditions. This metal-free protocol offers excellent functional group compatibility and avoids the usage of Lewis acids or oxidants, providing a sustainable and efficient approach to C–H acylation.

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